The glutathione S-transferase (GST) supergene family is considered a key enzymic detoxicating system that protects cells from endogenous and exogenous chemicals. Indeed, GST peptides are probably expressed in all life forms, implying their importance. However, despite identification of many in vitro substrates, the biological relevance of many of these is uncertain. Indeed, accumulating evidence also suggests a noncatalytic, cell signaling function for the GST.
Although many polymorphic sites have been examined for associations with disease susceptibility there is no clear view as to biochemical consequences of most alleles. We review GST gene organization and allelic sites and consider their possible functions. This forms a basis for selecting diseases potentially influenced by polymorphism.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.