The Human Genome Project has now provided a reestimate of the total number of genes within the human genome, and as specific links are made between genes and disease, the need for simple and cost-effective gene mutation detection becomes increasingly important. Nonetheless, the choice of test undertaken for any given screen presents a challenge, and in doing so, a number of considerations should be taken into account: 1) the level of throughput required; 2) the sensitivity and specificity permissible; 3) the resources available; 4) the speed with which a result is needed; and 5) cost.

Direct sequencing, for long considered the gold standard of mutation detection, is still costly and time-consuming; however, in terms of simplicity, heteroduplex analysis (HA) is unsurpassed in its application and analysis. This chapter will review the technique, its applications, and the latest developments which keep HA at the forefront of scanning technologies.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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