Introduction

The determination of the human genome generated much interest in using changes in levels of gene expression in individuals to discover the basis of disease and for the identification of new drug targets. Some significant advances have been made using this approach, and high-risk individuals can be identified. The ability to relate any changes seen to real conventional end points used in disease diagnosis remains elusive and much effort has been focused on the consequent protein level changes in tissues, cells, and biofluids (proteomics).

Metabonomics is another approach that provides data sets of similar high information content by systemic spectroscopic profiling of metabolites and metabolic pathways in whole organisms through study of biofluids and tissues. This results in complex multivariate data sets that require pattern recognition tools for interpretation, and the aim of these procedures is to extract biochemical information that is of diagnostic or other classification value. These identified substances become biomarkers that reflect actual biological events.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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