Introduction

Dilated cardiomyopathy (DCM) is a cardiac disorder characterized by dilatation of the left ventricle (LV) or both ventricles, with impaired systolic function. Familial DCM (FDCM) accounts for 25% of DCM. The clinical course of DCM/FDCM is determined by heart failure and arrhythmia with high morbidity and mortality despite progress in disease management. FDCM is inherited autosomal-dominant, autosomal-recessive, or X-linked. Mutations in at least 19 genes have been identified, indicating wide genetic heterogeneity and resulting in pure FDCM or distinct phenotypes of FDCM with other cardiac, muscle, or specific pathologies. Diseased proteins are localized in different cellular compartments. Because of wide phenotype and genotype heterogeneity, precise phenotype-genotype correlations are not available yet and predictors for clinical outcome are still largely undetermined.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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