Since their establishment in routine cytogenetics in the mid 1990s, multicolor fluorescence in situ hybridization (FISH) approaches have become indispensable for the identification and description of chromosomal rearrangements. The subsequent exact characterization of chromosomal breakpoints is of superior clinical impact and is the requisite condition for further molecular investigations aimed at the identification of disease-related genes. Thus, various approaches for a differentiation of chromosomal subbands based on multiplex FISH (M-FISH) assays were established. Here an overview is presented on available M-FISH banding methods including their advantages, limitations, and possible applications.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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