KCNH2 LQT2 and KCNE2 LQT6

KCNH2 and KCNE2 gene encode, respectively, for the alpha (HERG) and the beta (MiRP) subunit of the potassium channel conducting the IK current, the rapid component of the cardiac delayed rectifier (Fig. 1). LQT2

Fig. 1 Electrocardiogram (ECG) in the long QT syndrome. Examples of resting ECG in patients with a KCNQ1 mutation (A) and a KCNH2 mutation (B). Panel C shows a typical self-terminating polymorphic ventricular tachycardia in a LQTS patient. The arrhythmia was recorded by means of an insertable loop recorder (Revealâ„¢).

is the second most common variant of LQTS accounting for 35-40% of mutations (http://pc4.fsm.it:81/cardmoc). Functional expression studies have demonstrated that KCNH2 mutations cause a reduction of IKr current,[14] but, similarly to LQT1 mutations, this effect is realized through different biophysical mechanisms.[10] Mutations in the KCNE2 gene[15] cause the LQT6 variant of LQTS, which is the most uncommon subtype of the disease (<1%).

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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