Life Cycle

A common feature of all chlamydiae is the unique biphasic, strictly intracellular life cycle. The cycle starts with the attachment of small (~0.3 pm), metabolically inactive EBs to the host cell. After internalization, these transform into reticulate bodies (RBs; ~ 1 pm) which multiply by binary fission inside an inclusion. In the case of C. pneumoniae, these RBs begin to reorganize to EBs after 2 days, until finally the inclusion and cell rupture thereby releasing new EBs (Fig. 1).

In vitro a third state, the so-called persistent or aberrant state, can be induced by IFN-g, antibiotics, or depletion of nutrients.[3] When the inducing stimulus is removed these forms can reenter the normal developmental cycle.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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