Limitations And Future

It is important to note that PCR-based assays are more prone to different types of errors than those observed with hemagglutination assays. For instance, contamination with amplified products may lead to false-positive test results. In addition, the identification of a particular genotype does not necessarily mean that the antigen will be expressed on the RBC membrane.

A large number of people from a variety of ethnic backgrounds need to be studied to determine the occurrence of particular genotypes and to establish more firmly the correlation between blood group genotype and phenotype.

Advances are ongoing in the automation of SNP and DNA sequence analysis, and the success of sequencing the human genome has shown that the potential for phenotyp-ing large numbers of samples has already been real-ized.[34] It should soon be possible to analyze major and many minor blood group alleles on a single synthetic chip. Indeed, it will be possible to test for many genetically defined conditions.

As automated procedures attain higher and faster throughput at lower cost, blood group genotyping is likely to become more widespread. We believe that the PCR technology may be used in a transfusion service in the next few years to overcome the limitations of hemagglutination.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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