Low Penetrance And Variable Expressivity In Lqts

Likewise, as in other mendelian diseases, LQTS is characterized by a high degree of genetic heterogeneity and variable penetrance that translates into a range of possible phenotypes including subclinical forms with borderline of QT interval and no arrhythmias or syncope.[27,28] The demonstration of incomplete pene-trance in LQTS leads to the speculation that carriers' subclinical mutations, although not manifesting any phenotype, may be more susceptible to develop arrhythmias when exposed to precipitating factors. The prevalence of such variants in the population is not known, but it is appealing to speculate, and preliminary evidences exist,[29] that these defects may have a role in modulating the phenotype and may create a vulnerable substrate.[15,30]

these modifiers in the general population to define their role in arrhythmogenesis.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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