Management

Without hemostatic challenge, patients with factor XI deficiency do not need treatment. In case of dental extractions or surgical intervention, fresh frozen plasma replacement therapy may be required. This can be combined with the application of antifibrinolytic agents. The half-life of factor XI in plasma is about 40-80 hr, and factor XI function is well preserved.1-9-1 For dental extractions, only antifibrinolytic therapy using tranexamic acid from 12 hr before until 7 days after the procedure has also proven to be effective.[6,9] Other products such as fibrin glue or desmopressin have been used in a limited number of patients as well.[9] In general, it is recommended to continue therapy for several days. Factor XI concentrates have been developed but are presently not licensed for use in the United States.

In patients with factor XI inhibitors, the uses of prothrombin complex concentrates and recombinant factor VIIa were successful.1-6-1

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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