Management of Thalassemia Major

Patients affected by thalassemia major are treated with regular blood transfusions and iron chelation therapy with desferrioxamine B (DFO). Life expectancy with this treatment extends to the third decade. The alternative oral iron chelator deferiprone (L1) is indicated only in patients with proven allergy or toxicity from DFO. Alternative chelation strategies and drugs, including the combination of deferiprone and DFO or ICL670 alone, are under investigation.

Bone marrow transplantation (BMT) or cord blood transplantation from HLA-identical siblings represents an alternative to traditional transfusion and chelation therapy. In patients without liver fibrosis and low level of iron accumulation, the disease-free survival is over 90%. However, BMT from HLA-identical but unrelated donors has a lower (60%) disease-free survival.[4-6]

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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