As FX levels do not correlate with clinical phenotype, therapy of FX deficiency is based on the presence of bleeding manifestations. Transfusion with fresh frozen plasma may be used to treat symptomatic patients. A level of 10-20% U/dL is usually sufficient for adequate hemostasis. The half-life of FX is approximately 40 hr. Plasma is administered with an initial dose of 15 mL/kg, followed by 3-6 mL/kg every 24 hr.

Prothrombin complex concentrates, i.e., FIX, contain a small quantity of FX (about 1 U FX per unit of FIX). Although these concentrates have been shown to be effective in the treatment of bleeding episodes in patients with FX and FVII deficiency, their use has been associated with significant thrombogenicity.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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