The 5594-nucleotide, single-stranded DNA genome of parvovirus B19 is flanked by identical palindromic inverted terminal repeats of 382 nucleotides at each end of the genome, which are required in cis for replication. Transcription of two main open reading frames (ORFs), which encode one nonstructural protein (NS1) and two virion polypeptides (VP1 and VP2), is initiated at the p6 promoter on the extreme left end of the plus-strand genome (Table 1). At least nine differentially spliced transcripts are generated.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.