Molecular Characterization Of The Epsteinbarr Virus

Classification of EBV is based on both phenotypic and genomic sequence variations.[18] Type 1 (type A) and type 2 (type B) EBV strains are distinguished on the molecular level by sequence variations in the viral genes encoding the EBV-associated nuclear antigens (EBNAs). Both types of EBV can be easily identified by PCR.

Characterization and identification of EBV strains has also been reported by Western blot assays based on variations in the molecular weight of the EBNA proteins.

In the context of NPC, a number of sequence variations within the transforming viral LMP-1 gene have been found. Virus strains with a characteristic 30-base-pair deletion have been statistically detected more often in NPC compared to asymptomatic virus carriers. Another strain variation reported to be present in southern Chinese patients with NPC is the "f' variant.

In context with severe chronic active infections with EBV, virus strains with a bias to lytic replication and an impaired or even absent capacity to establish latent infection have been reported.[19-21]

In conclusion, molecular characterization of Epstein-Barr viral strains is only of minor importance for routine diagnostics and therapy. The role of distinct EBV strains in pathogenesis is only indicated by circumstantial evidence. Furthermore, molecular analysis of EB viral strains in individuals revealed infection with multiple strains of EBV, with the type of strains in the oropharynx and in the peripheral blood shifting over time.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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