The Stanford Genome Technology Center has recently sequenced the entire diploid genome of C. albicans. Covering 1.6 x 107 bp, with eight pairs of chromosomes and containing over 9000 genes encoding proteins of at least 100 amino acids, it is larger and shares only 60% gene homology with the genome of Saccharomyces cerevisiae—the organism often used to predict antifungal targets in C. albicans}14,15 Compared to S. cerevisiae, C. albicans has more genes that are specific to it—a factor that could account for its pathogenicity and ability to colonize various environments.1-16-1
Within the genome, 567 genes have been designated as essential for survival, with an estimated 1400 genes required for growth. The genome contains several large gene families encoding proteases, lipases, and cell wall proteins, and, together with genes distinct to C. albicans, are considered good targets for antifungal agents. Furthermore, different strains of C. albicans have varying numbers of rDNA units, with some strains possessing over 200 copies, making it an ideal target for molecular-based identification methods.
Was this article helpful?
The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.