Molecular Characterization

The Stanford Genome Technology Center has recently sequenced the entire diploid genome of C. albicans. Covering 1.6 x 107 bp, with eight pairs of chromosomes and containing over 9000 genes encoding proteins of at least 100 amino acids, it is larger and shares only 60% gene homology with the genome of Saccharomyces cerevisiae—the organism often used to predict antifungal targets in C. albicans}14,15 Compared to S. cerevisiae, C. albicans has more genes that are specific to it—a factor that could account for its pathogenicity and ability to colonize various environments.1-16-1

Within the genome, 567 genes have been designated as essential for survival, with an estimated 1400 genes required for growth.[15] The genome contains several large gene families encoding proteases, lipases, and cell wall proteins, and, together with genes distinct to C. albicans, are considered good targets for antifungal agents.[14] Furthermore, different strains of C. albicans have varying numbers of rDNA units, with some strains possessing over 200 copies,[17] making it an ideal target for molecular-based identification methods.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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