Molecular Genetic Testing Genetic Counseling And Clinical Management

Molecular genetic testing in familial melanoma is currently considered premature by the International Melanoma Genetics Consortium1-23-1 for the following reasons. First, the mutation detection rate in melanoma families is very low. Second, risk estimates for mutation carriers are not well established (and have broad confidence intervals). In particular, the risk for other cancers, such as pancreatic cancer, is not clearly defined. Third, surveillance programs for mutation carriers have not yet been proven to be effective, questioning the medical benefit of the DNA test result. The last and most critical reason for not currently offering genetic testing in familial melanoma is the increased risk for melanoma in nonmutation carriers in CDKN2A mutation-positive families. Predictive DNA testing then should only be offered within the bounds of a clearly defined research protocol. In this setting, extensive genetic counseling addressing the limited value of testing in familial melanoma is a prerequisite. Such research protocols might offer possibilities to explore the still pending issues concerning the risk benefit and potential value of genetic testing for familial melanoma. They will need to address efficient screening protocols for melanoma and pancreatic cancer in the hope of leading to a decrease in mortality by earlier detection. Outside of such research investigations, clinical management of familial melanoma should be restricted to recognition of high-risk individuals and subsequent yearly or half-yearly skin examination from age 10-12 onward. The strong decrease in life expectancy with increasing tumor thickness makes early recognition of melanoma through regular skin examinations the hallmark of clinical management.

How To Prevent Skin Cancer

How To Prevent Skin Cancer

Complete Guide to Preventing Skin Cancer. We all know enough to fear the name, just as we do the words tumor and malignant. But apart from that, most of us know very little at all about cancer, especially skin cancer in itself. If I were to ask you to tell me about skin cancer right now, what would you say? Apart from the fact that its a cancer on the skin, that is.

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