Molecular Genetic Testing

RS! is the only gene known to be associated with RS. Molecular genetic analysis is an effective approach for the early detection of at-risk males, carrier detection, and prenatal diagnosis.[27] The phenotype of RS is sufficiently variable that Eksandh et al.[28] emphasized the importance of supplementary molecular genetic testing in boys with visual failure of unknown etiology. Three mutations within the RS! gene, E72K (214G> A), G74V (221G >T), and G109R (325G >C), are associated commonly with RS in individuals of Finnish descent. Approximately 95% of patients of Finnish heritage have one of these three founder mutations.[29] Mutation analysis for these mutations is available on a clinical basis. Sequence analysis of the six exons of the RS! gene identifies nearly 90% of males with a clinical diagnosis of RS, and mutational analyses are available at various clinical centers (http:// www.geneclinics.org).[27]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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