DM1 is caused by an unstable CTG expansion in the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene on chromosome 19q13.3 (Table 1). Affected subjects are usually heterozygous for the expansion. Only six homozygous subjects have been reported. In affected subjects the repeat length varies between 50 and 5000. Alleles with 50-80 repeats are
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.