Molecular Genetics

In about 60% of cases, HCM is inherited as autosomal-dominant FHC. The prevalence is 1/500 in the common adult population. In the typical form of FHC, mutations in 12 different disease genes encoding proteins of the sarcomere have been identified (Table 1 and Fig. 1). Four genes encode the thick filaments: MYH7 for p-myosin heavy chain (p-MyHC) and MYH6 for a-myosin heavy chain (a-MyHC), MYL3 for essential myosin light chain (MLC-1), and MYL2 for regulatory myosin light chain (MLC-2); five genes encode the thin filaments: ACTC for

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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