Monitoring The Development Of Antiretroviral Resistance

There are currently 18 drugs licensed for use against HIV-1 and they are shown in Table 1. The compounds are active against the viral protease (protease inhibitors) and reverse transcriptase ( nucleoside, nucleotide, and nonnucleoside analogues) enzymes. Other drugs in development include compounds directed against other viral targets such as integrase inhibitors and fusion inhibitors. Point mutations that confer resistance to nucleoside analogues and protease inhibitors appear to be similar for both HIV-1 and HIV-2.[14] However, HIV-2 isolates appear to be resistant to nonnucleoside reverse transcriptase inhibitors (NNRTIs) because of preexisting polymorphisms.1-15-1 Mutations that

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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