Monozygotic Twins

Somatic mutations can occur early in embryonic life and may involve both somatic cells and germ cells. These individuals (gonosomal mosaics) may then be at risk of having affected children. A new mutation often first appears in a mosaic form, usually in a clinically normal person, who then has a constitutionally affected child. Van der Maarel et al.[12] detected somatic mosaicism in 40% of their de novo FSHD families (14% in an unaffected parent and 26% of the de novo FSHD patients themselves).

Several studies have reported considerable variation in the clinical expression of FSHD in pairs of affected monozygotic twins.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook

Post a comment