Mouse Model

To gain further insight into the function of the RS1 gene and its role in the cellular pathology of RS, Weber et al.[38] generated knockout mice deficient in the mouse gene, RS1h. The RS1h~/Y male mouse has a retinal phenotype which closely resembles the human disease. These mice show generalized disruption of retinal cell layer architecture, splitting of the inner retinal layer with gaps between bipolar cells, and disruption of the synapses between photoreceptors and bipolar cells. These findings suggest that retinoschisin may be directly or indirectly involved in retinal cell layer architecture and structural properties of the retinal synapse.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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