Mutated cKit As A Novel Target Of Therapy

Because the c-kit mutation D816V is a recurrent defect considered to be of pathogenetic significance, recent attempts have focused on agents that may be capable of inhibiting the kinase activity of D816V c-kit. A first promising observation has been that the tyrosine kinase inhibitor STI571 that is successfully applied in chronic myeloid leukemia (CML) is also capable of inhibiting the c-kit tyrosine kinase.[31,32] Moreover, it has been shown that STI571 downregulates (SCF-dependent) in vitro growth of human MCs at pharmacological concentrations.1-33-1 However, unfortunately, the D816V-mutated form of c-kit is far less susceptible to STI571 compared to the WT receptor.[32,34] Therefore current research is focusing on novel inhibitory drugs that may counteract c-kit D816V.[35]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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