Nat And Drug Response

The genetic polymorphism in N-acetyltransferase activity was first discovered in patients treated with isoniazid for tuberculosis. This drug is primarily excreted following acetylation catalyzed by NAT2. Many other therapeutic

Table 1 Effect of acetylator status on drug response and toxicity

Drug

Phenotype

Effect

Reference

Dapsone

Slow

Neurotoxicity

[24,25]

Sulfamethoxazole

Slow

Hypersensitivity

[26]

Hydralazine

Slow

Systemic lupus erythematosus

[27]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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