Overview

The recently available microarray technology is a powerful new tool to assess the expression of a large number of genes in a single experiment. The most important use of array technology in medical science is to characterize global gene expression profiles, which are specific for disease subgroups or have prognostic value (e.g., for disease progression). The aim of those studies is to accelerate the identification of diagnostic and prognos tic markers, and to identify novel tumor-specific markers for certain malignant diseases.

One of the groundbreaking studies[1] using oligonu-cleotide microarrays showed that global gene expression analysis can distinguish with high accuracy between leukemic blasts from patients with either AML or acute lymphoblastic leukemia (ALL). Subsequently, a number of studies[2-4] analyzing different kinds of tumor entities including malignant lymphomas or solid tumors (e.g., breast cancers carrying mutations of BRCA1 and BRCA2) were performed by demonstrating the power of microarray analyses to correlate specific gene expression profiles with well-established classification/ prognostic systems.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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