Overview

Hepatitis C virus genotypes may differ by as much as 33% of their nucleotide sequence distributed over the entire viral genome. Different HCV isolates are distinguished based on their genetic similarity in genotypes, which further separate into subtypes. All HCV isolates fall into phylogenetically related clusters called subtypes. Subtypes can be classified into several major types (sequence similarities of 65-75%).[1] Eleven genotypes as well as more than 90 subtypes have been identified.[2,3] Despite a high degree of sequence conservation in the 5'UTRs, genotype-specific differences exist in this region. Based on sequence variations in the 5'UTR and the NS5 region, Simmonds et al.[4,5] proposed a classification of HCV types and subtypes confirmed by phylogenetic tree analysis, which is currently most often used. Therapeutical management of chronic HCV infection has been based on the HCV genotype as recommended in Consensus Statements published by the European Association of the Study of the Liver and the National Institutes of Health.[6,7]

Nucleotide sequencing of the entire HCV genome followed by composition of a phylogenetic tree has been

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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