The main clinical and pharmaceutical areas where metabonomics is impacting include

• Validating animal models of disease, including genetically modified animals.

• Preclinical evaluation of drug safety, ranking of candidate compounds, assessment of safety in clinical trials and after product launch, evaluation of the effects of interactions between drugs, and between drugs and diet, and providing new measures of pharmaceutical efficacy.

• Improved diagnosis of human diseases, especially chronic and degenerative diseases.

• Better understanding of human population differences (epidemiological studies) and patient stratification for clinical trials and drug treatment (pharmaco-metabonomics).

Metabonomics yields time-dependent patterns of change in response to disease or drug effects. One role for metabonomics therefore is to direct timing of pro-teomic and genomic analyses to maximize the probability of observing ''omic'' biological changes that are relevant to functional outcomes.

Metabonomics, defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification,[1,2] bridges the gap between other -omics measurements and real-world end points. Metabolites can easily be identified and quantified, and changes can be related to health and disease, and are changeable by therapeutic intervention. There have been a number of reviews of metabonomics recently.[3,4]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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