Fig. 2 a-Galactosidase gene representation showing the position of exons and the distribution of some mutations (del = deletion; IVS = intervening sequence).

gene comprised of seven exons, with introns ranging from 200 bp to 3.7 kb (Fig. 2).[11,12] Exon 1 contains the 5' untranslated region, the sequence encoding the signal peptide, and a sequence for the first 33 residues of the mature enzyme. The full-length cDNA, containing a 1290-bp coding sequence, encodes the 398 residues of the mature enzyme subunit.[13] A particularity of the a-galactosidase cDNA is the absence of 3' untranslated region. The polyadenylation signal sequence is in the coding region, 12 bp from the termination codon, which is followed by the poly (A) tract.

Mutations in the a-Gal A gene

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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