P53 Oncosuppressor Gene

The first role of p53 to be discovered was in tumor generation. p53 gene has the features of a recessive onco-suppressor in its wild-type form, and it can be a dominant oncogene in its mutated form. Mutations in the p53 oncosuppressor gene occur in most of human cancers, and regulation of the protein is defective in a variety of others (for review see Ref. [1]).

Recently, two proteins, p73 and p63, have been identified as members of the p53 gene family. Unlike p53, both p73 and p63 are rarely mutated in human cancers, and their involvement in tumor generation is still to be clarified.[2]

The p53 gene (20 kbp) is located in a single copy on the short arm of chromosome 17 and contains 11 exons interrupted by 10 introns. It codes for a protein of 393 amino acids consisting of at least four functional and regulatory domains: the N-terminus contains the trans-activation domain; the central domain is responsible for sequence-specific DNA binding; the oligomerization domain ensures assembly of p53 into conformationally active tetramers; and the C-terminus contains a negative regulatory domain whose posttranslational modification may play an important role in modulating the specific activity of p53.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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