Diarrhea during Cryptosporidium infection is associated with intestinal malabsorption and enhanced secretion. Infection can lead to blunting of intestinal villi, hyperplasia of crypt cells, and enterocyte brush border damage incurred during parasite invasion. Diarrhea may be a result of increased secretion as a result of ion imbalance following responses to secreted cytokines such TNFa, INFg, IL-8, and substance P. The list of parasite molecules that may act as specific virulence factors during infection is growing (Table 1). In contrast, protective host cell responses such as host cell-triggered apoptosis and secretion of TGF-p1 and IL-10 may limit epithelial cell damage.[4,12,14]
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.