Pharmacogenetics has a threefold role in the pharmaceutical industry, which is relevant to the development of personalized medicines:[7]

1. For study of the drug metabolism and pharmacological effects

2. For predicting genetically determined adverse reactions

3. Drug discovery and development and as an aid to planning clinical trials

It is of considerable importance to know the metabolic status of an individual, particularly when using drugs with a narrow therapeutic range. Differences in metabolism of drugs can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Inter- and intra-individual variability in pharmacokinetics of most drugs is largely determined by variable liver function as described by parameters of hepatic blood flow and metabolic capacity. Among the factors affecting these parameters are genetic differences in metabolizing enzymes. The most important of these is P450.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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