Pharmacogenomic Applications

Several benefits arise from incorporating genotyping analysis in pharmacogenomics studies. Genotyping results are not affected by diet, drug-drug interactions, or disease progression. Unlike phenotyping, test accuracy is not dependent on steady-state metabolism of the therapeutic. In addition, genotyping results are not dependent on the methodology used. By genotyping individuals suffering adverse drug reactions, specific genetic profiles associated with risk can be identified. Optimizing drug selection and dosing for poor and ultra metabolizers will not only result in increased effectiveness of treatment, but also reduce the need for multiple phenotypic evaluations.

The overall effectiveness of a given therapeutic will be determined by a combination of genetic loci encoding transporters, receptors, and metabolizing enzymes. The use of electronic microarrays to analyze panels of SNPs in such genes will allow greater accuracy in determination of the therapeutic effect and potential toxicity of therapeutics. Such a personalized panel represents the ultimate goal and promise of pharmacogenomics. Electronic mi-croarrays can provide a valuable tool in the efforts to facilitate development of such panels and incorporate them into clinical practice.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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