Current applications of pharmacogenomics in drug development include prospective genotyping in Phase I trial to ensure that a subject population is representative with respect to drug metabolism phenotypes. Inclusion and exclusion of patients may be based on genotypes. The banking of genetic material from later stage trials for retrospective studies on drug response is becoming more frequent, but is not yet standard in the industry. Retrospective studies using collections of DNA that supply medical information on specific disease types, drug response, and ethnic composition could build a foundation for the evolution of medicine from diagnosis and treatment toward prediction and prognosis which are important components of integrated personalized medi-
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.