There is an increasing interest in proteomics technologies now because DNA sequence information provides only a static snapshot of the various ways in which the cell might use its proteins whereas the life of the cell is a dynamic process. Pharmacoproteomics will play an important role in the development of personalized medicine because proteomics-based characterization of multifactorial diseases may help to match a particular target-based therapy to a particular marker in a subgroup of patients. Individualized therapy may be based on differential protein expression rather than a genetic polymorphism. Advantages of using pharmacoproteomics are:
• Pharmacoproteomics is a more functional representation of patient-to-patient variation than that provided by genotyping.
• Because it includes the effects of posttranslational modification, pharmacoproteomics connects the genotype with the phenotype.
Pharmacoproteomics could increase the predictability of early drug development and identify noninvasive biomarkers of toxicity or efficacy.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.