Pon1 And Drug Metabolism

Evidence exists that PON1 may be involved in the metabolism of pharmaceutical drugs, in which case the

PON1 status of an individual would be relevant to a drug's effectiveness and/or side effects. The diuretic spironolac-tone is hydrolyzed by PON1, with similar efficiency by the Q and R isoforms.[25] However, the hypocholester-olemic drugs mevastatin, lovastatin, and simvastatin, previously reported to be hydrolyzed by PON1, are instead metabolized by PON3.[12] The antibacterial prodrug prolifloxacin is activated by PON1, with PON1r192 displaying higher activity. However, glucocorticoid g-lactones are inactivated by PON1. Although evidence is still limited, novel classes of so-called prodrugs may be developed by incorporating a lactone or cyclic carbonate moiety into their molecules, which can be inactivated or bioactivated in vivo by PON1.[11,12,26]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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