Currently, there is no therapy that cures SMA. However, active investigations are underway, and new therapeutic approaches will likely emerge in the near future. Potential therapeutic approaches (reviewed in Refs. [11,19]) are: 1) to increase full-length mRNA from SMN2 by an in vivo alteration in the splicing pattern of SMN2 exon 7 through activation of trans-acting factors, or antisense RNA molecules; 2) to increase the overall transcription level of SMN mRNA by activating the SMN promoter; 3) to stabilize the SMN protein; 4) to repair degenerated motor neurons; 5) to replace degenerated motor neurons by stem cell therapy; and 6) to target modifying factors other than SMN2. A high throughput drug screening for the identification of compounds that up-regulate full-length SMN protein is underway.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.