Potential Therapeutics

Currently, there is no therapy that cures SMA. However, active investigations are underway, and new therapeutic approaches will likely emerge in the near future. Potential therapeutic approaches (reviewed in Refs. [11,19]) are: 1) to increase full-length mRNA from SMN2 by an in vivo alteration in the splicing pattern of SMN2 exon 7 through activation of trans-acting factors, or antisense RNA molecules; 2) to increase the overall transcription level of SMN mRNA by activating the SMN promoter; 3) to stabilize the SMN protein; 4) to repair degenerated motor neurons; 5) to replace degenerated motor neurons by stem cell therapy; and 6) to target modifying factors other than SMN2. A high throughput drug screening for the identification of compounds that up-regulate full-length SMN protein is underway.

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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