Cystic fibrosis is a relatively common recessive disorder in Caucasian populations, having a carrier frequency of about 1 in 29 and a birth incidence of 1 in 2500. Carrier rates in the other major ethnic groups of the United States have been estimated at 1 in 46 for Hispanic Americans, 1 in 65 for African Americans, and 1 in 90 for Asian Americans.[5] As noted, the predominant mutation in

Caucasian carriers is AF508, but most of the other > 1000 mutations are extremely rare or even ''private'' (found only in a single family). Perhaps the most accessible population for general carrier screening are Ashkenazi Jews, in whom the high prevalence of the W1282X mutation (45% of carriers) and three others in addition to AF508 yields a high screening sensitivity of 97%.[6] At the other end of the spectrum are Asians (and Asian Americans), in whom the disease frequency is low and the mutations are rare and/or not characterized, leading to some controversy over whether these populations should be screened.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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