MCAD deficiency and PKU are most prevalent among target diseases in Western countries, and the estimated incidence of these diseases is 1:10,000-20,000.[15,16] However, in Asian countries, these two diseases are rather rare, but some organic acidemias and citrin deficiency may be common.
Of 1.0-1.2 million newborns studied in the Neo Gen Screening, the following were detected: 65 patients with MCAD deficiency, 3 with very long chain acyl-CoA dehydrogenase deficiency, 3 with short-chain acyl-CoA dehydrogenase deficiency, 2 with long-chain hydroxy acyl-CoA dehydrogenase deficiency, and 2 with carnitine palmitoyltransferase II deficiency among fatty acid oxidation disorders; 68 patients with PKU, 65 with hyper-phenylalaninemia, 12 with MSUD, 5 with ASS deficiency, and 2 with ASL deficiency among aminoacidopathies; and 13 patients with glutaric aciduria type I (GA-1), 15 with 3MCC deficiency, 9 with MMA, and 6 with PA among organic acidemias. Of about 0.18 million newborns in Japan, the following were detected: six patients with PA, two with MMA, three with GA-1, two with multiple acyl-CoA dehydrogenation deficiency, two with MCAD deficiency, four with citrin deficiency, and two with PKU.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.