R752h

NR= No report.

aThese data do not include gene mutations that cause heritable forms of anemia associated with iron overload.

NR= No report.

aThese data do not include gene mutations that cause heritable forms of anemia associated with iron overload.

with a form of hemochromatosis (OMIM #604250) in several racial and ethnic groups.[31-36] The mutations originally reported in Sicilian families[31] were considered to be rare based on other investigators failure to observe them associated with iron overload in several racial/ethnic groups.[37'38] However, mutations in TFR2 when present with HFE mutations could also modify the penetrance of an iron overload phenotype.[36]

Mutations in the ferroportin 1 gene (FPN1), located on chromosome 2q32, are associated with an autosomal dominant form of hemochromatosis (OMIM #606069) in several racial and ethnic groups.[39-48]

Although it is likely that there will be cases of iron overload due to various combinations of mutations in the genes just described, this possibility has not been extensively explored. The frequency in which mutations in these genes appear in various racial/ethnic groups varies. Thus, it is likely that the combination of mutations found associated with iron overload will also vary by racial/ethnic group. This will have to be considered in the selection of cohorts to assess these possibilities. Current large multiethnic screening studies in diverse geographic regions may provide answers to these questions and predict more precisely who will develop iron over-

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Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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