Readingframe Rule Of Dmdbmd

Although both DMD and BMD patients have been shown to have deletion or duplication mutations of the dystrophin gene, the extent of the deletion does not always correlate with the severity of the disease: some BMD patients with mild symptoms have deletions encompassing numerous exons, whereas some DMD patients with severe symptoms lack only a few exons. In some cases, the long deletions resulting in BMD and the short deletions resulting in DMD may even overlap. The reading-frame rule explains the difference between DMD and BMD as follows: in DMD the translational reading frame of the dystrophin mRNA is shifted after a deletion or duplication mutation whereas it is maintained in BMD.[3] According to the reading-frame rule, BMD patients with long deletions are able to produce dystrophin mRNA that would still direct the production of an internally truncated semifunctional protein. Shorter deletions harbored by severe DMD patients, on the other hand, would bring together exons that, when spliced, would change the translational reading frame in the mRNA, such that a

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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