1. Chick, W.L.; Pema, J.J.; Lauris, V.; Low, D.; Galletti, P.M.; Panol, G.; Whittemore, A.D.; Like, A.A.; Colton, C.K.; Lysaght, M.J. Artificial pancreas using living beta cells: Effects on glucose homeostasis in diabetic rats. 13. Science 1977, 197, 780-782.

2. Winn, S.R.; Zielinski, B.; Tresco, P.A.; Signore, A.P.; Jaeger, C.B.; Greene, L.A.; Aebischer, P. Behavioral recovery following intrastriatal implantation of microencapsulated PC12 cells. Exp. Neurol. 1991, 113, 322- 14. 329.

3. Emerich, D.F.; Lindner, M.D.; Saydoff, J.; Gentile, F.T. Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells. In Fetal Transplantation in Neurological Diseases; Freeman, T.B., 15. Widner, H., Eds.; Humana Press: NJ, 1998; 253-286.

4. Emerich, D.F.; Winn, S.R. Immunoisolation cell therapy for CNS diseases. Crit. Rev. Ther. Drug Carr. Syst. 2001, 18, 265-299. 16.

5. Mathiowitz, E. Encyclopedia of Controlled Drug Delivery; Wiley and Sons: New York, 1999.

6. Gentile, F.T.; Doherty, E.J.; Rein, D.H.; Shoichet, M.S.; Winn, S.R. Polymer science for macroencapsulation of cells for central nervous system transplantation. J. React. Polym. 1995, 25, 207-227.

7. Dionne, K.E.; Cain, B.M.; Li, R.H.; Bell, W.B.; Doherty, 17. E.J.; Rein, D.H.; Lysaght, M.J.; Gentile, F.T. Transport characterization of membranes for immunoisolation. Biomaterials 1996, 17, 257-266.

8. Winn, S.R.; Tresco, P.A. Hydrogel Applications for Encapsulated Cellular Transplants. In Methods in Neuro- 18. science, Vol 21, Providing Pharmacological Access to the Brain; Flanagan, T.F., Emerich, D.F., Winn, S.R., Eds.; Academic Press: Orlando, FL, 1994; Vol. 21, 387-402.

Lysaght, M.J.; Aebischer, P. Encapsulated cells as therapy. Sci. Am. 1999, 280, 77-82.

The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group. A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. Clin. Neuropharmacol. 1995,18, 515-532. Aebischer, P.; Schleup, M.; Deglon, N.; Joseph, J.-M.; Hirt, L.; Heyd, B.; Goddard, M.; Hammang, J.P.; Zurn, A.D.; Kato, A.C.; Regli, F.; Baetge, E.E. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat. Med. 1996, 2, 696-699.

Zurn, A.D.; Henry, H.; Schluep, M.; Aubert, V.; Winkel, L.; Eilers, B.; Bachman, C.; Aebischer, P. Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically-engineered xenogeneic cells. Cell Transplant 2000, 9, 471-484. Emerich, D.F.; Lindner, M.D.; Winn, S.R.; Chen, E.-Y.; Frydel, B.; Kordower, J.H. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci. 1996, 1, 5168-5181. Emerich, D.F.; Winn, S.R.; Hantraye, P.M.; Peschanski, M.; Chen, E.-Y.; Chu, E.; McDermott, P.; Baetge, E.E.; Kordower, J.H. Protective effects of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 1997, 386, 395-399. Kordower, J.H.; Isacson, O.; Emerich, D.F. Cellular delivery of trophic factors for the treatment of Huntington's disease: Is neuroprotection possible? Exp. Neurol. 1999, 59, 4-20.

Bachoud-Levi, A.C.; Deglon, N.; Nguyen, J.P.; Bloch, J.; Bourdet, C.; Winkel, L.; Remy, P.; Goddard, M.; Lefaucher, J.P.; Brugieres, P.; Baudic, S.; Cesaro, P.; Peschanski, M.; Aebischer, P. Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum. Gene Ther. 2000, 11, 1723-1729. Cayouette, M.; Behn, D.; Sendtner, M.; Lachapelle, P.; Gravel, C. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J. Neurosci. 1998, 18, 9282-9293.

Tao, W.; Wen, R.; Goddard, M. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2002, 43, 3292-3298.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook

Post a comment