1. Allen, B.A.; Terdiman, J.P. Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer. Best Pract. Res. Clin. Gastroenterol. 2003, 17 (2), 237258.

2. Boardman, L.A. Heritable colorectal cancer syndromes: Recognition and preventative management. Gastroenterol. Clin. 2002, 31 (4), 1107-1131.

3. Amos, C.I.; Frazier, M.L.; McGarrity, T.J. Peutz-Jeghers syndrome. GeneReviews 2003. (Accessed March 2004).

4. Hemminki, A.; Tomlinson, I.; Markie, D.; Jarvinen, H.; Sistonen, P.; Bjorkqvist, A.; Knuutila, S.; Salovaara, R.; Bodmer, W.; Shibata, D.; de la Chapelle, A.; Aaltonen, L.A. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat. Genet. 1997, 15 (1), 87-90.

5. Amos, C.I.; Bali, D.; Thiel, T.J.; Anderson, J.P.; Gourley, I.; Frazier, M.L.; Lynch, P.M.; Luchtefeld, M.A.; Young, A.; McGarrity, T.J.; Seldin, M.F. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res. 1997, 57 (17), 3653-3656.

6. McGarrity, T.J.; Kulin, H.E.; Zaino, R.J. Peutz-Jeghers syndrome. Am. J. Gastroenterol. 2000, 95 (3), 596-604.

7. Tomlinson, I.P.M.; Houlston, R.S. Peutz-Jeghers syndrome. J. Med. Genet. 1997, 34, 1007-1011.

8. Bronner, M.P. Gastrointestinal inherited polyposis syndromes. Mod. Pathol. 2003, 16 (4), 359-365.

9. Giardiello, F.M.; Welsh, S.B.; Hamilton, S.R.; Offerhaus, G.J.; Gittelsohn, A.M.; Booker, S.V.; Krush, A.J.; Yardley, J.H.; Luk, G.D. Increased risk of cancer in the Peutz-Jeghers syndrome. N. Engl. J. Med. 1987, 316 (24), 15111514.

10. Giardiello, F.M.; Brensinger, J.D.; Tersmette, A.C.; Goodman, S.N.; Petersen, G.M.; Booker, S.V.; Cruz-Correa, M.; Offerhaus, J.A. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology 2000, 119 (6), 1447-1453.

11. Boardman, L.A.; Thibodeau, S.N.; Schaid, D.J.; Lindor, N.M.; McDonnell, S.K.; Burgart, L.J.; Ahlquist, D.A.; Podratz, K.C.; Pittelkow, M.; Hartmann, L.C. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann. Intern. Med. 1998, 128 (11), 896-899.

12. Lim, W.; Hearle, N.; Shah, B.; Murday, V.; Hodgson, S.V.; Lucassen, A.; Eccles, D.; Talbot, I.; Neale, K.; Lim,

A.G.; O'Donohue, A.; Donaldson, A.; Macdonald, R.C.; Young, I.D.; Robinson, M.H.; Lee, P.W.R.; Stoodley,

B.J.; Tomlinson, I.; Alderson, D.; Holbrook, A.G.; Vyas, S.; Swarbrick, E.T.; Lewis, A.A.M.; Phillips, R.K.S.; Houlston, R.S. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br. J. Cancer 2003, 89, 308-313.

13. Boardman, L.A.; Couch, F.J.; Burgart, L.J.; Schwartz, D.; Berry, R.; McDonnell, S.K.; Schaid, D.J.; Hartmann, L.C.; Schroeder, J.J.; Stratakis, C.A.; Thibodeau, S.N. Genetic heterogeneity in Peutz-Jeghers syndrome. Human Mutat. 2000, 16, 23 - 30.

14. Mehenni, H.; Blouin, J.L.; Radhakrishna, U.; Bhardwaj, S.S.; Bhardwaj, K.; Dixit, V.B.; Richards, K.F.; Bermejo-Fenoll, A.; Leal, A.S.; Raval, R.C.; Antonarakis, S.E. Peutz-Jeghers syndrome: Confirmation of linkage to chromosome 19p13.3 and identification of a potential second locus, on 19q13.4. Am. J. Hum. Genet. 1997, 61 (6), 1327-1334.

15. Hemminki, A.; Markie, D.; Tomlinson, I.; Avizientye, E.; Roth, S.; Loukola, A.; Bignell, G.; Warren, W.; Aminoff, M.; Hoglund, P.; Jarvinen, H.; Kristo, P.; Pelin, K.; Ridanpaa, M.; Salovaara, R.; Toro, T.; Bodmer, W.; Olschwang, S.; Olsen, A.S.; Stratton, M.R.; de la Chapelle, A.; Aaltonen, A.L. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998, 391 (6663), 184-187.

16. Jenne, D.E.; Reimann, H.; Nezu, J.; Friedel, W.; Loff, S.; Jeschke, R.; Muller, O.; Back, W.; Zimmer, M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat. Genet. 1998, 18 (1), 38-43.

17. Ylikorkala, A.; Avizienyte, I.P.; Tomlinson, I.P.; Tiainen, M. Roth, S.; Loukola, A.; Hemminki, A.; Johansson, M. Sistonen, P.; Markie, D.; Neale, K.; Phillips, R.; Zauber, P. Twama, T.; Sampson, J.; Jarvinen, H.; Makela, T.P. Aaltonen, L.A. Mutations and impaired function of LKB1

in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum. Mol. Genet. 1999, 8, 45-51.

18. Westerman, A.M.; Entius, M.M.; Boor, P.P.C.; Koole, R.; de Baar, E.; Offerhaus, G.J.A.; Lubinski, J.; Lindhout, D.; Halley, D.J.J.; de Rooij, F.W.M.; Wilson, J.H.P. Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families. Human Mutat. 1999, 13 (6), 476481.

19. Mehenni, H.; Gehrig, C.; Nezu, J.; Oku, A.; Shimane, M.; Rossier, C.; Guex, N.; Blouin, J.; Scott, H.S.; Antonarakis, S.E. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am. J. Hum. Genet. 1998, 63, 1641-1650.

20. Tiainen, M.; Ylikorkala, A.; Makela, T. Growth suppression by LKB1 is mediated by a G1 cell cycle arrest. Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 9248-9251.

21. Tiainen, M.; Vaahtomeri, K.; Ylikorkala, A.; Makela, T. Growth arrest by the LKB1 tumor suppressor: Induction of p21WAF1/CIP1. Hum. Mol. Genet. 2002,11 (13), 1497-1504.

22. Karuman, P.; Gozani, O.; Odze, R.D.; Zhou, X.C.; Zhu, H.; Shaw, R.; Brien, T.P.; Bozzuto, C.D.; Ooi, D.; Cantley, L.C.; Yuan, J. The Peutz-Jeghers gene product LKB1 is a mediator of p53-dependent cell death. Mol. Cell 2001, 7 (6), 1307-1319.

23. Nezu, J.; Oku, A.; Shimane, M. Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients. Biochem. Biophys. Res. Commun. 1999, 261 (3), 750-755.

24. Ylikorkala, A.; Rossi, D.J.; Korsisaari, N.; Luukko, K.; Alitalo, K.; Henkemeyer, M.; Makela, T.P. Vascular

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