1. Kimonis, V.E.; Goldstein, A.M.; Pastakia, B. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am. J. Med. Genet. 1997, 69 (3), 299-308.

2. Michaelsson, G.; Olsson, E.; Westermark, P. The Rombo syndrome: A familial disorder with vermiculate atropho-derma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. Acta Derm. Venereol. 1981, 61, 497-503.

3. Bazex, A.; Dupre, A.; Christol, B. Genodermatose complexe de type indetermine associant une hypotrichose, un etat atrophodermique generalise et des degenerescences cutanees multiples (epitheliomas-basocellulaires). Bull. Soc. Fr. Dermatol. Syphiligr. 1964, 71, 206.

4. Ming, J.E.; Kaupas, M.E.; Roessler, E.; Brunner, H.G.; Golabi, M.; Stratton, R.F.; Sujansky, E.; Bale, S.J.; Muenke, M. Mutations in Patched-1, the receptor for Sonic Hedgehog, are associated with holoprosencephaly. Hum. Genet. 2002, 110, 297 - 301.

5. Taipale, J.; Cooper, M.K.; Maiti, T.; Beachy, P.A. Patched acts catalytically to suppress the activity of smoothened. Nature 2002, 418, 892- 896.

6. Incardona, J.P.; Gruenberg, J.; Roelink, H. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr. Biol. 2002, 12, 983-995.

7. Zeng, X.; Goetz, J.A.; Suber, L.M.; Scott, W.J., Jr.Schreiner, C.M.; Robbins, D.J. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature 2001, 411, 716-720.

8. Cohen, M.M., Jr. The Hedgehog signalling network. Am. J. Genet. 2003, 123 (A), 5-28.

9. McCarthy, R.A.; Barth, J.L.; Chintalapudi, M.R.; Knaak, C.; Argraves, W.S. Megalin functions as an endocytic Sonic hedgehog receptor. J. Biol. Chem. 2002, 277, 25660-25667.

10. Kalderon, D. Transducing the hedgehog signal. Cell 2000, 103, 371-374.

11. Capdevila, J.; Pariente, F.; Sampedro, J.; Alonso, J.L.; Guerrero, I. Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development 1994, 120, 987-998.

12. Incardona, J.P.; Lee, J.H.; Robertson, C.P.; Enga, K.; Kapur, R.P.; Roelink, H. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proc. Natl. Acad. Sci. U. S. A. 2000, 97 (22), 12044-12049.

13. Strutt, H.; Thomas, C.; Nakano, Y.; Stark, D.; Neave, B.; Taylor, A.M.; Ingham, P.W. Mutations in the sterol-

sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol. 2001, 11, 608-613.

14. Karpen, H.E.; Bukowski, J.T.; Hughes, T.; Gratton, J.-P.; Sessa, W.C.; Gaillani, M.R. The Sonic hedgehog receptor Patched associates with Caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J. Biol. Chem. 2001, 276, 19503-19511.

15. Barnes, E.A.; Kong, M.; Ollendorff, V.; Donoghue, D.J. Patched1 interacts with cyclin Bl to regulate cell cycle progression. EMBO J. 2001, 20, 2214-2223.

16. Denef, N.; Neubuser, D.; Perez, L.; Cohen, S.M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000, 102, 521-531.

17. Taipale, J.; Chen, J.K.; Cooper, M.K.; Wang, B.; Mann, R.K.; Milenkovic, L.; Scott, M.P.; Beachy, P.A. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 2000, 406, 1005-1009.

18. Hogervorst, F.B.L. The protein truncation test (PTT). Promega Notes Magazine 1997, 62, 7.

19. Pomeroy, S.L.; Tamayo, P.; Gaasenbeek, M.; Sturla, L.M.; Angelo, M.; McLaughlin, M.E.; Kim, J.Y.H.; Goumnerova, L.C.; Black, P.M.; Lau, C.; Allen, J.C.; Zagzag, D.; Olson, J.M.; Curran, T.; Wetmore, C.; Biegel, J.A.; Poggio, T.; Mukherjee, S.; Rifkin, R.; Califano, A.; Stolovitzky, G.; Louis, D.N.; Mesirov, J.P.; Lander, E.S.; Golub, T.R. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002, 415, 436-442.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook

Post a comment