Regulation Of Expression

Regulation of expression varies between GST classes. In the promoter, response elements to transcription factors including the antioxidant response element, xenobiotic response element, glucocorticoid response element, Barbie box element, and GSTP enhancer 1 have been identified. Motifs for YY1, AP-1, MAF, Nrfl, Jun, Fos, and NK-kB have also been identified in rodents, although not all have been confirmed in human GST.[1,2] Such elements suggest an adaptive response by the GST to cellular stress.

A further mechanism for influencing GST expression is via methylation of CpG islands. In particular, GSTP1 expression appears particularly important in the protection of prostatic cells from oxidant and electrophile stress as methylation in the promoter silences expression allowing genetic damage and progression toward carcinoma.[7] Several studies have shown virtually 100% methylation of the GSTP1 CpG island in prostatic cancer cells.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook


Post a comment