Repertoire And Biochemistry Of S Pyogenes Superantigens

The repertoire of S. pyogenes SAgs includes 11 structurally and functionally related, single-chain proteins with molecular weights ranging from ca. 23 to 27 kDa.[14] Most of these proteins have been purified to homogeneity. The repertoire comprises: 1) the classical erythrogenic (scarlatinal) toxins A and C (due to their likely association with scarlet fever), also designated streptococcal pyrogenic exotoxins A and C (SPE A, SPE C); 2) a series of recently discovered mitogenic exoproteins, called streptococcal superantigen (SSA), streptococcal mitogenic exotoxin (SMEZ), and the pyrogenic toxins SPE G, SPE H, SPE I, SPE J, SPE K, SPE L, and SPE M, respectively.[4,9-11,14,16] The occurrence of these exotoxins discovered over the past 12 years was inferred for some of them from genome mapping of serotypes M1, M3, and M18 GAS. The respective genes were further transcribed, and the super-antigenicity and lethality of corresponding SAg proteins established.[16] Serological studies showed the presence of antibodies against these SAgs.[4]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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