In a subset of the SMA patients who do not lack both copies of SMN1, ~30 small intragenic mutations (''subtle'' or ''nondeletion'' mutations) in SMN1 have been identified (reviewed in Ref. [10,11]), for which we proposed the use of standard nomenclature.[10] These intra-genic mutations provide solid evidence that SMN1 is indeed the SMA gene, because intragenic SMN1 mutations are associated with the SMA phenotype regardless of the status of other candidate genes. The three most frequently reported small intragenic mutations are the Y272C missense mutation (815A>G), the 768_778dupTGCT-GATGCTT frameshift mutation, and the 399_402delA-GAG frameshift mutation.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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