Standard Of Care

SNPs cDNA

cDNA

Antibody

Antibody

Pilot studies and Retrospective Clinical Analyses

Prospective Confirmatory Analyses

Multiinstitutional Validation Trials

Oligonucleotide

Fig. 3 The use of high-throughput technologies provides novel targets that might be developed into biomarkers of diagnostic and prognostic utility. The tumor marker development requires several steps before acceptance into clinical routine. (View this art in color at www.dekker.com.)

versatility for high-throughput screening for biomarker discovery using, for example, mass spectrometry. Protein microarrays also provide means of rapidly validating the genes identified by expression profiling using DNA microarrays at the protein level.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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