Pilot studies and Retrospective Clinical Analyses
Prospective Confirmatory Analyses
Multiinstitutional Validation Trials
Fig. 3 The use of high-throughput technologies provides novel targets that might be developed into biomarkers of diagnostic and prognostic utility. The tumor marker development requires several steps before acceptance into clinical routine. (View this art in color at www.dekker.com.)
versatility for high-throughput screening for biomarker discovery using, for example, mass spectrometry. Protein microarrays also provide means of rapidly validating the genes identified by expression profiling using DNA microarrays at the protein level.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.