The 12-kb gene is located on the long arm of chromosome 14 in a cluster of other serpins, and two major promoters have been identified: one for hepatocytes, the cell type accounting for most of the circulating AAT, and the other, which is effective in other tissues such as monocytes and lung alveolar epithelial cells. The gene is made up of four coding exons and three noncoding exons, and, during mRNA expression, the noncoding exons are differentially spliced. A diagrammatic representation of the gene is shown in Fig. 3.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.