The miniaturization of electrochemical DNA biosen-sors[1-3] enabled the mass production of disposable sensor strips. These sensor strips have gradually taken the place of the conventional three-electrode system consisting of bulky working, reference, and counter electrodes, and beakers with a large amount of buffer and analyte solution volume, mostly ranging between 1 and 2 mL. However, the disposable sensor strips alone can be described as disposable electrochemical cells, which contain the working, reference, and counter electrodes together on a minimal scale and space. A small droplet of the buffer and an analyte solution of about 20 mL would be sufficient for an electrochemical reaction to take place. Especially, the ''memory-effects'' resulting from the insufficient cleaning of the electrode surface have been completely eliminated with these single-use sensor strips. Thus more reproducible results could be obtained by using a new electrode for each experiment. Such a significant decrease in the required analyte volume, and increase in reproducibility while shrinking the required space in the laboratory, had a revolutionary impact on the field of electrochemical biosensors, so that the term ''on-field analysis'' has become possible with the help of the miniaturization of such electrochemical potentiostats and sensor strips, enabling ''bedside clinical diagnosis'' and ''on-site environmental monitoring.'' Even the diabetes patients themselves have become capable of measuring their own blood glucose levels by using such small handheld electrochemical devices in connection with sensor strips. Nowadays, the biggest challenge facing electro-chemists is to develop such a small device, which can perform nucleic acid-based tests with a simple and rapid procedure, as well as high sensitivity and selectivity.
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