Although type I is, by definition, nonneuronopathic, and the presence of the N370S allele obviates neurological involvement, nonetheless, recent data are suggestive of a phenotypical continuum that includes some neurological signs even in patients with type I. Among the earliest anecdotal reports were those of parkinsonism that is marked by early onset, aggressive progression, and refractoriness to conventional anti-Parkinson therapy in patients with very mild type I Gaucher disease.
Similarly, the very-early-onset type II or the ''neonatal form' ' has been proposed wherein onset of signs is in the neonatal period, and is in conjunction with other overt abnormalities including ichthyosis, hydrops fetalis, and/or collodion baby.
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The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.